Development_Neural stem cell lineage commitment (schema)
Development_Schema: FGF signaling in embryonic stem cell self-renewal and differentiation
Development_Positive regulation of WNT/Beta-catenin signaling at the receptor level
Main genetic and epigenetic alterations in lung cancer
Transcription_HIF-1 targets
Development_Schema: Adult neuron differentiation in the Subventricular and Subgranular Zones
TGF-beta signaling via SMADs in breast cancer
Role of epigenetic alterations in survival and migration of SCLC cells
Role of epigenetic alterations in proliferation and differentiation of SCLC cells
Muscle contraction_Role of kappa-type opioid receptor in heart
Autocrine Somatotropin signaling in breast cancer
Neuropeptide signaling in pancreatic cancer
Development_TGF-beta family mediated differentiation of embryonic stem cells
Neurophysiological process_Kappa-type opioid receptor signaling in the central nervous system
Development_Negative regulation of WNT/Beta-catenin signaling at the receptor level
Role of DNA methylation in progression of multiple myeloma
Development_Transcription factors in segregation of hepatocytic lineage
WNT signaling in HCC
Development_Astrocyte differentiation from adult stem cells
Epigenetic alterations in ovarian cancer
Tinnitus-associated changes in auditory pathway
Stromal-epithelial interaction in Prostate Cancer
Mast cell migration in asthma
Development_BMP signaling in cardiac myogenesis
Immune response_HMGB1/TLR signaling pathway
Development_YAP/TAZ-mediated co-regulation of transcription
Development_H3K36 demethylation in stem cell maintenance
Stellate cells activation and liver fibrosis
Butanoic acid metabolism
Signal transduction_MIF signaling pathway
Development_Negative regulation of STK3/4 (Hippo) pathway and positive regulation of YAP/TAZ function
Immune response_IL-4-induced regulators of cell growth, survival, differentiation and metabolism
Regulation of metabolism_Bile acids regulation of glucose and lipid metabolism via FXR
Development_Neurotrophin family signaling
Putative pathways for stimulation of fat cell differentiation by Bisphenol A
Putative roles of SETDB1 and PLU-1 in melanoma
Role of Leptin in regulation of eating behavior in obesity
Development_Delta- and kappa-type opioid receptors signaling via beta-arrestin
G-protein signaling_Regulation of CDC42 activity
Role of metalloproteases and heparanase in progression of pancreatic cancer
Hedgehog signaling in breast cancer
Development_Thrombopoietin signaling via ERK1/2 and PI3K
Role of Nicotine-induced Leptin resistance in hypothalamus in development of obesity
Resolution of inflammation in healing myocardial infarction
Immune response_Inflammasome in inflammatory response
NALP3 inflammasome activation in age-related macular degeneration (AMD)
Beta-catenin-dependent transcription regulation in colorectal cancer
Upregulation of MITF in melanoma
wtCFTR and deltaF508 traffic / Membrane expression (normal and CF)
Gamma-secretase regulation of osteogenesis
IL-6 signaling in colorectal cancer
Development_Retinoic acid and retinoic acid receptors in regulation of oligodendrocyte differentiation
Development_Early embryonal hypaxial myogenesis
GLP-1 in beta cell apoptosis in type 2 diabetes
Activation of TGF-beta signaling in pancreatic cancer
Regulation of VEGF signaling in pancreatic cancer
Signal transduction_mTORC1 downstream signaling
Role of inflammasome in macrophages, adipocytes and pancreatic beta cells in type 2 diabetes
Development_Role of proteases in hematopoietic stem cell mobilization
Cell cycle_Regulation of G1/S transition (part 1)
Cell adhesion_Cell-matrix glycoconjugates
Development_Oligodendrocyte differentiation (general schema)
Apoptosis and survival_IL-17-induced CIKS-dependent NF-kB signaling and mRNA stabilization
Tumor-stroma interactions in pancreatic cancer
Development_Astrocyte differentiation (general schema)
Development_PEDF signaling
Protein folding and maturation_Posttranslational processing of neuroendocrine peptides
Development_BMP7 in brown adipocyte differentiation
HGF signaling in melanoma
Development_Schema: Adult neurogenesis in the Subventricular Zone
Cell adhesion_Desmosomes
Pro-oncogenic action of PTHrP in breast cancer
Prostate Cancer: candidate susceptibility genes in inflammatory pathways
IL-6 signaling in multiple myeloma
Inhibition of Vitamin D pathway in Prostate Cancer
G protein-coupled receptors signaling in lung cancer
Signal transduction_Angiotensin II/ AGTR1 signaling via TGF-beta 1 and SMADs
Role of adipose tissue hypoxia in obesity and type 2 diabetes
Immune response_HMGB1/RAGE signaling pathway
Inhibition of apoptosis in gastric cancer
PXR-mediated direct regulation of xenobiotic metabolizing enzymes / Human version
Canonical WNT signaling pathway in colorectal cancer
SHH signaling in colorectal cancer
Role of inhibition of WNT signaling in the progression of lung cancer
Development_Generation of pancreatic beta-cells from embryonic stem cells (early stages)
Role of ZNF202 in regulation of expression of genes involved in atherosclerosis
Development_Schema: Embryonal myogenesis
Inflammatory mechanisms of pancreatic cancerogenesis
HGF receptor (Met) and MSP receptor (RON) signaling pathways in SCLC
Immune response_IL-15 signaling via JAK-STAT and PPAR cascades
Regulation of Tissue factor signaling in cancer
Cell adhesion_ECM remodeling
ATP metabolism
Cell cycle_Role of Nek in cell cycle regulation
Inhibition of LKB1 / AMPK signaling in breast cancer
Development_Schema: Histone H3 demethylases in stem cells
Signal transduction_mTORC2 downstream signaling
Role of fibroblasts in the sensitization phase of allergic contact dermatitis
Inhibition of RUNX3 signaling in gastric cancer
Development_BMP signaling
The innate immune response to contact allergens
Cell cycle_Spindle assembly and chromosome separation
Normal and pathological TGF-beta-mediated regulation of cell proliferation
Nicotine signaling in glutamatergic neurons
Role of nicotine in pathogenesis of SCLC
Cytoskeleton remodeling_FAK signaling
G-protein signaling_Regulation of Cyclic AMP levels by ACM
Signal transduction_PDGF signaling via PI3K/AKT and NFkB pathways
Mechanisms of drug resistance in SCLC
Immune response_IL-4-responsive genes in type 2 immunity
Action of GSK3 beta in bipolar disorder
Development_Thrombopoietin signaling via JAK-STAT pathway
Development_NODAL signaling in early mesendoderm formation
Development_Epigenetic and transcriptional regulation of oligodendrocyte precursor cell differentiation and myelination
Development_Role of cell-cell and ECM-cell interactions in oligodendrocyte differentiation and myelination
Role of Apo-2L(TNFSF10) in Prostate Cancer cell apoptosis
Nociception_Expression and role of Nociceptin in immune system
Transport_RAB3 regulation pathway
Th2-cytokines induced expression of Mucin 5AC and maintenance of mucous cell phenotype in normal airway epithelium
Pro-oncogenic action of Androgen receptor in breast cancer
NF-kB pathway in multiple myeloma
Dual role of TGF-beta 1 in HCC
Retinoic acid regulation of oligodendrocyte differentiation in multiple sclerosis
Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway
Neurophysiological process_Dopamine D2 receptor signaling in CNS
TGF-beta-induced fibroblast/ myofibroblast migration and extracellular matrix production in asthmatic airways
IL-17-induced mucin expression in CF airways
Development_Role of Thyroid hormone in regulation of oligodendrocyte differentiation
Cytoskeleton remodeling_Keratin filaments
E-cadherin signaling and its regulation in gastric cancer
Inhibition of apoptosis in multiple myeloma
Development_Thrombospondin 1 signaling
Effect of H. pylori infection on inflammation in gastric epithelial cells
Stem cells_Aberrant Hedgehog signaling in medulloblastoma stem cells
Development_Melanocyte development and pigmentation
Th17 cells in CF (mouse model)
Regulation of CFTR activity (normal and CF)
Nicotine / nAChR alpha-3/nAChR beta-2 signaling in NSCLC
CREB1-dependent transcription deregulation in Huntington's Disease
Immune response_Role of HMGB1 in dendritic cell maturation and migration
Inhibition of TGF-beta signaling in gastric cancer
Neurophysiological process_Corticoliberin signaling via CRHR1
Transcription_Role of AP-1 in regulation of cellular metabolism
Regulation of lipid metabolism_Regulation of lipid metabolism via LXR, NF-Y and SREBP
Role of tumor-infiltrating B cells in anti-tumor immunity
Development_Inhibition of angiogenesis and regulation of endothelial cell function by PEDF
Development_Regulation of epithelial-to-mesenchymal transition (EMT)
Development_Oligodendrocyte differentiation from adult stem cells
Signal transduction_NF-kB activation pathways
Development_The role of GDNF ligand family/ RET receptor in cell survival, growth and proliferation
NRSF-dependent transcription deregulation in Huntington's Disease
Resistance of melanoma cells to Apo-2L(TNFSF10)-induced apoptosis
Signal transduction_BMP signaling via BMPR1A and BMPR1B receptors
PXR-mediated direct regulation of xenobiotic metabolizing enzymes / Rodent version
Blood coagulation_Blood coagulation
Immune response_CD40 signaling
Development_TGF-beta receptor signaling
Development_Self-renewal of adult neural stem cells
Influence of bone marrow cell environment on progression of multiple myeloma
Neurophysiological process_Synaptic vesicle fusion and recycling in nerve terminals
Oxidative stress_ROS-induced cellular signaling
Activation of Cortisol production in major depressive disorder
Immune response_Th1 and Th2 cell differentiation
Apoptosis and survival_NGF activation of NF-kB
Role of Ghrelin in activation eating behavior in obesity
Development_FGF signaling in pancreatic and hepatic differentiation of embryonic stem cells
Involvement of VEGF signaling in the progression of lung cancer
Main pathways of Schwann cells transformation in neurofibromatosis type 1
L-Tryptophan metabolism (part 1)
Dysregulation of direct glucose-induced inhibition of Glucagon secretion from alpha-cells in type 2 diabetes
Immune response_Inhibitory PD-1 signaling in T cells
Signal transduction_CXCR4 signaling via MAPKs cascades
B-regulatory cells and tumor cells intercellular interaction
Development_VEGF-family signaling
Development_Regulation of lung epithelial progenitor cell differentiation
Immune response_B cell antigen receptor (BCR) pathway
Neurophysiological process_Dynein-dynactin motor complex in axonal transport in neurons
Immune response_HSP60 and HSP70/ TLR signaling pathway
Disruption of apoptosis, proliferation and shedding of epithelial cells in asthma
Hedgehog signaling in gastric cancer
Abnormalities in cell cycle in SCLC
Adiponectin in pathogenesis of type 2 diabetes
Bone metastases in Prostate Cancer
Transcription_Assembly of RNA Polymerase II preinitiation complex on TATA-less promoters
Androgen signaling in HCC
Populations of skin dendritic cells involved in contact hypersensitivity
Tau pathology in Alzheimer disease
PGE2 pathways in cancer
Role of Thyroid hormone in regulation of oligodendrocyte differentiation in multiple sclerosis
Apoptosis and survival_Apoptotic TNF-family pathways
FAK1 signaling in melanoma
Serotonin modulation of dopamine release in nicotine addiction
Transcription_FXR-regulated cholesterol and bile acids cellular transport
GLP-1 in inhibition of beta cell proliferation and function in type 2 diabetes
Chemoresistance pathways mediated by constitutive activation of PI3K pathway and BCL-2 in small cell lung cancer
Signal transduction_WNT/Beta-catenin signaling in tissue homeostasis
Stem cells_Neovascularization of glioblastoma in response to hypoxia
Development_Role of BMP signaling in embryonic stem cell neural differentiation
Apoptosis and survival_Granzyme A signaling
Development_WNT/Beta-catenin signaling in cell differentiation
Signal transduction_Additional pathways of NF-kB activation (in the nucleus)
Immune response_IL-5 signaling via JAK/STAT
Th2-cytokines-induced expression of mucins in asthma
Role of platelets in the initiation of in-stent restenosis
Development_WNT/Beta-catenin signaling in embryogenesis
MicroRNAs in melanoma
Deregulation of canonical WNT signaling in major depressive disorder
Epithelial cell apoptosis in COPD
Blood coagulation_GPCRs in platelet aggregation
Macrophage and dendritic cell phenotype shift in cancer
Main chemotherapy drugs and their action in SCLC cells
TGF-beta 1-mediated induction of EMT in normal and asthmatic airway epithelium
Role of TLR signaling in skin sensitization
Transition of HCC cells to invasive and migratory phenotype
Hyaluronic acid/ CD44 signaling in cancer
TGF-beta signaling via kinase cascades in breast cancer
Stem cells_Cooperation between Hedgehog, IGF-2 and HGF signaling pathways in medulloblastoma stem cells
Cell cycle_Role of APC in cell cycle regulation
WNT signaling in invasive-type melanoma cells
Activation of ACTH production in pituitary gland in major depressive disorder
EZH2 in Prostate Cancer
Apoptosis and survival_IL-17-induced CIKS-dependent MAPK signaling pathways
Development_Direct reprogramming of cardiac fibroblasts into cardiomyocytes
Neurophysiological process_Olfactory transduction
Apo-2L(TNFSF10)-induced apoptosis in melanoma
SCAP/SREBP Transcriptional Control of Cholesterol and FA Biosynthesis
Regulation and signaling of HGF receptor (Met) and MSP receptor (RON) in lung cancer
Development_Regulation of cytoskeleton proteins in oligodendrocyte differentiation and myelination
Immune response_Naive CD4+ T cell differentiation
High shear stress-induced platelet activation
Neurophysiological process_Regulation of intrinsic membrane properties and excitability of cortical pyramidal neurons
Apoptosis and survival_Granzyme B signaling
Resistance of pancreatic cancer cells to death receptor signaling
Prolactin signaling in Prostate Cancer
Development_Self-renewal and pluripotency maintenance of human embryonic stem cells
Signal transduction_Activin A signaling regulation
SHH signaling in melanoma
Chondroitin sulfate and dermatan sulfate metabolism
Development_Regulation of endothelial progenitor cell differentiation from adult stem cells
Putative pathways of MHC class I-dependent postsynaptic long-term depression in major depressive disorder
Nicotine signaling (general schema)
Inhibition of tumor suppressive pathways in pancreatic cancer
Cell cycle_Cell cycle (generic schema)
Inhibition of remyelination in multiple sclerosis: role of cell-cell and ECM-cell interactions
Development_TGF-beta-dependent induction of EMT via MAPK
Regulation of lipid metabolism_PPAR regulation of lipid metabolism
Regulation of angiogenesis in prostate cancer
Development_FGF2 signaling during embryonic stem cell differentiation
Disruption of epithelial layer restitution in asthma
Immune response_IFN-alpha/beta signaling via JAK/STAT
Chemokines in inflammation in adipose tissue and liver in obesity, type 2 diabetes and metabolic syndrome X
Stimulation of TGF-beta signaling in lung cancer
PXR signaling via cross-talk / Rodent version
PXR signaling via cross-talk / Human Version
Cell cycle_Role of 14-3-3 proteins in cell cycle regulation
B cell signaling in hematological malignancies
Interleukins-induced inflammatory response in asthmatic airway fibroblasts
Role of osteoblasts in bone lesions formation in multiple myeloma
Plasminogen activators signaling in pancreatic cancer
Production and activation of TGF-beta in airway smooth muscle cells
Development_TGF-beta-dependent induction of EMT via SMADs
Th2 cytokine- and TNF-alpha-induced inflammatory response in asthmatic airway fibroblasts
Development_Extraembryonic differentiation of embryonic stem cells
Immune response_Th17 cell differentiation
Extracellular matrix-regulated proliferation of airway smooth muscle cells in asthma
Langerhans cell migration to lymph nodes in allergic contact dermatitis
Glucose-excited neurons of arcuate nucleus in obesity (rodent model)
Apoptosis and survival_CXCR3-B signaling
Transcription_Sirtuin6 regulation and functions
Role of EPAS1 in obesity
HIF-1 in gastric cancer
Development_PTHR1 in bone and cartilage development
HGF signaling in colorectal cancer
Cell cycle_Sister chromatid cohesion
Apoptosis and survival_Beta-2 adrenergic receptor anti-apoptotic action
Stem cells_Aberrant Wnt signaling in medulloblastoma stem cells
Prolactin/ ERK signaling in breast cancer
WNT signaling in gastric cancer
Neurophysiological process_Thyroliberin in cell hyperpolarization and excitability
Immune response_IL-4 signaling pathway
Transport_The role of AVP in regulation of Aquaporin 2 and renal water reabsorption
Neurophysiological process_Leptin signaling in neurons
TGF-beta 1-induced transactivation of membrane receptors signaling in HCC
Angiogenesis in HCC
VEGF signaling in multiple myeloma
Rheumatoid arthritis (general schema)
Survival pathways in Prostate Cancer
Immune response_IFN-gamma in macrophages activation
The role of PTEN and PI3K signaling in melanoma
Signal transduction_CXCR4 signaling via second messengers and JAK/STAT
Development_Role of IL-8 in angiogenesis
Muscle contraction_Regulation of eNOS activity in endothelial cells
Immune response_Generation of memory CD4+ T cells
Role of alveolar cell senescence in COPD
Development_Signaling pathways in embryonic hepatocyte maturation
Development_Endothelial differentiation during embryonic development
Dual role of p53 in transcription deregulation in Huntington's Disease
Development_Signaling of Beta-adrenergic receptors via Beta-arrestins
Signal transduction_PDGF signaling via JAK-STAT and reactive oxygen species (ROS)
Macrophage-induced immunosuppression in the tumor microenvironment
Immune response_TCR alpha/beta signaling pathway
Immune response_Lysophosphatidic acid signaling via NF-kB
Glucagon-induced glucose upregulation in type 2 diabetes in liver
Signal transduction_Cyclic AMP signaling
Role of TGF-beta 1 in fibrosis development after myocardial infarction
IgE-dependent production of pro-inflammatory mediators by neutrophils in asthma
Eosinophil-derived cytokines in airway remodeling in asthma
Development_Negative regulation of WNT/Beta-catenin signaling in the cytoplasm
Role of neuropeptides in pathogenesis of SCLC
Putative pathways of activation of monoclonal protein secretion in multiple myeloma
Development_Cross-talk between VEGF and Angiopoietin 1 signaling pathways
Immune response_LPS-induced platelet activation
Transcription_Transcription regulation of aminoacid metabolism
Apoptosis and survival_Role of nuclear PI3K in NGF/ TrkA signaling
Activation of pro-oncogenic TGF-beta potential in gastric cancer
Development_ROBO2, ROBO3 and ROBO4 signaling pathways
Fenofibrate in treatment of type 2 diabetes and metabolic syndrome X
Apoptosis and survival_Caspase cascade
Development_Insulin, IGF-1 and TNF-alpha in brown adipocyte differentiation
Regulation of VEGF expression in lung cancer
Non-genomic signaling of ESR2 (membrane) in lung cancer cells
TLRs-mediated IFN-alpha production by plasmacytoid dendritic cells in SLE
Immune response_Induction of the antigen presentation machinery by IFN-gamma
EGFR signaling pathway in lung cancer
Cytoskeleton remodeling_PDGF signaling via calcium and Rho GTPases
Immune response_Th17, Th22 and Th9 cell differentiation
Development_PACAP signaling in neural cells
Role of neurotrophins in activation of p53 in major depressive disorder
Cell cycle progression in Prostate Cancer
Signal transduction_Leptin signaling via JAK/STAT and MAPK cascade
Apoptosis and survival_APRIL and BAFF signaling
Cytoskeleton remodeling_RalB regulation pathway
SHH signaling in oligodendrocyte precursor cells differentiation in multiple sclerosis
SLE genetic marker-specific pathways in antigen-presenting cells (APC)
Huntington's disease (general schema)
Dysregulation of indirect glucose-induced inhibition of Glucagon secretion from alpha-cells in type 2 diabetes
Th17 cells in CF
Growth factors in regulation of oligodendrocyte precursor cells proliferation in multiple sclerosis
Immune response_OX40L/ OX40 signaling pathway
Hypothetical role of microRNAs in fibrosis development after myocardial infarction
Cell cycle_Initiation of mitosis
Pioglitazone and Rosiglitazone in treatment of type 2 diabetes and metabolic syndrome X
CAR signaling via cross-talk / Human Version
Neurophysiological process_Glucose-excited neurons of arcuate nucleus (rodent model)
Stem cells_NOTCH1-induced self-renewal of glioblastoma stem cells
Development_Role of Activin A in cell differentiation and proliferation
Development_H3K27 demethylases in differentiation of stem cells
Transcription_Role of heterochromatin protein 1 (HP1) family in transcriptional silencing
Development_SLIT-ROBO1 signaling
IL-1 beta- and Endothelin-1-induced fibroblast/ myofibroblast migration and extracellular matrix production in asthmatic airways
Role of IGH translocations in multiple myeloma
Stem cells_Response to hypoxia in glioblastoma stem cells
Proteases and EGFR-induced mucin synthesis in normal and asthmatic epithelium
Immune response_T regulatory cell-mediated modulation of effector T cell and NK cell functions
Immune response_IL-3 signaling via ERK and PI3K
Role of Bregs in attenuation of T and NK cells mediated anti-tumor immune responses
Breast cancer (general schema)
Signaling Transduction_Role of MIF as an intracellular mediator
Stem cells_Inhibition of Hedgehog signaling in medulloblastoma stem cells
Immune response_IL-6 signaling pathway via JAK/STAT
Pancreatic cancer cell resistance to Tarceva (erlotinib)
CAR signaling via cross-talk / Rodent version
Histamine metabolism
Neurophysiological process_GABA-A receptor life cycle
Insulin-dependent stimulation of SREBP-1 in type 2 diabetes in liver
Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/IAP pathway
Platelet activation as a result of endothelial dysfunction after stenting
Apoptotic pathways and resistance to apoptosis in lung cancer cells
Development_VEGF signaling and activation
Transcription targets of Androgen receptor involved in Prostate Cancer
Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
IL-1 signaling in melanoma
Skeletal muscle atrophy in COPD
Ca(2+)-dependent NF-AT signaling in cardiac hypertrophy
Immune response_Role of PKR in stress-induced antiviral cell response
Signal transduction_Angiotensin II signaling via Beta-arrestin
Neurophysiological process_GABA-B receptor signaling in presynaptic nerve terminals
Role of Diethylhexyl Phthalate and Tributyltin in fat cell differentiation
Development_Regulation of CDK5 in CNS
HGF signaling in pancreatic cancer
Immune response_Innate immune response to RNA viral infection
Platelet activation during ADAM-TS13-deficient thrombotic microangiopathy development
The role of aberrations in CDKN2 locus and CDK4 in familial melanoma
IL-17 and IL-17F-induced inflammatory signaling in normal and asthmatic airway epithelium
Th1 and Th17 cells in an autoimmune mechanism of emphysema formation in smokers
Reproduction_Gonadotropin-releasing hormone (GnRH) signaling
CHDI_Correlations from Discovery data_Causal network
Neurophysiological process_Thyroliberin signaling
Immune response_Regulatory role of C1q in platelet activation
Effect of H. pylori infection on gastric epithelial cell proliferation
NMDA-independent presynaptic long-term potentiation in Huntington's disease
Immune response_IL-7 signaling in B lymphocytes
Prostaglandins and leukotrienes-mediated induction of expression of mucins in normal and asthmatic epithelium
POMC, alpha-MSH and AGRP in regulation of food intake and energy expenditure in obesity in hypothalamus
Regulation of proinflammatory cytokine production by Th2 cells in asthma
Role of cell adhesion in vaso-occlusion in Sickle cell disease
Immune response_BAFF-induced canonical NF-kB signaling
Role of Insulin in regulation of eating behavior in obesity
Role of platelets in allograft rejection
Apoptosis and survival_Regulation of apoptosis by mitochondrial proteins
Immune response_IL-12 signaling pathway
T follicular helper cell dysfunction in SLE
Cell cycle_Role of SCF complex in cell cycle regulation
Suppression of TGF-beta signaling in pancreatic cancer
Cigarette smoke-mediated regulation of NRF2-antioxidant pathway in airway epithelial cells
Cholesterol and Sphingolipid transport / Influx to the early endosome in lung (normal and CF)
Apoptosis and survival_p53-dependent apoptosis
Neurophysiological process _Visual perception
Signal transduction_Somatostatin signaling via SSTR2
Development_Activation of Erk by ACM1, ACM3 and ACM5
Development_Estrogen-independent activation of ESR1 and ESR2
Catecholamine metabolism
EGFR signaling pathway in colorectal cancer
Role of stellate cells in progression of pancreatic cancer
Oxidative stress_Role of Sirtuin1 and PGC1-alpha in activation of antioxidant defense system
Aberrant lipid trafficking and metabolism in age-related macular degeneration pathogenesis
Immune response_IL-17 signaling pathways
Stimulation of gastric acid secretion in gastric cancer
Immune response_TREM1 signaling pathway
Sorafenib-induced inhibition of cell proliferation and angiogenesis in HCC
Development_WNT/Beta-catenin signaling in organogenesis
Gamma-secretase regulation of angiogenesis
Retinoic acid maintains mucocilliary differentiation and mucins expression in normal and asthmatic airway epithelium
Role of SHH and Notch in SCLC
Regulation of IGF family activity in colorectal cancer
Role of prenatal nicotine exposure in apoptosis and proliferation of pancreatic beta cells
Transcription_Ligand-dependent activation of the ESR1/SP pathway
Putative role of Tregs in COPD
DNA damage_G2 checkpoint in response to DNA mismatches
Colorectal cancer (general schema)
Putative pathways of Oleic acid sensing in ventromedial hypothalamus in obesity (rodent model)
Role of IFN-beta in activation of T cell apoptosis in multiple sclerosis
Cytoskeleton remodeling_RalA regulation pathway
Nicotine signaling in chromaffin cells
Neurophysiological process_Glutamic acid regulation of Dopamine D1A receptor signaling
Development_EPO-induced MAPK pathway
Immune response_TNF-R2 signaling pathways
Signal transduction_Angiotensin II/ AGTR1 signaling via JAK/STAT
L-Lysine metabolism
Immune response_IL-3 signaling via JAK/STAT, p38, JNK and NF-kB
Development_c-Kit ligand signaling pathway during hemopoiesis
Blood coagulation_GPIb-IX-V-dependent platelet activation
Role of activation of WNT signaling in the progression of lung cancer
Signal transduction_CXCR4 signaling via PI3K cascade
Role of GIP in pathogenesis of type 2 diabetes
Serotonin - melatonin biosynthesis and metabolism
Apoptosis and survival_IL-17-induced CIKS-independent signaling pathways
Neurophysiological process_Receptor-mediated axon growth repulsion
Inhibition of TGF-beta signaling in lung cancer
Development_Embryonal epaxial myogenesis
IL-1 production in melanoma
Immune response_Induction of apoptosis and inhibition of proliferation mediated by IFN-gamma
Signal transduction_JNK pathway
Regulation of mast cell survival in asthma
Development_HGF signaling pathway
Development_TNF-alpha, IL-1 alpha and WNT5A-dependent regulation of osteogenesis and adipogenesis in mesenchymal stem cells
Chemotaxis_Lysophosphatidic acid signaling via GPCRs
Degranulation of lung mast cells
O-glycan biosynthesis
Role of IL-6 in obesity and type 2 diabetes in adipocytes
Development_H3K4 demethylases in stem cell maintenance
Noise-induced hair cell death and spiral ganglion neuron degeneration
Development_Androgen receptor in non-reproductive systems development
Development_Androgen receptor in reproductive system development
Muscle contraction_Relaxin signaling pathway
Neurophysiological process_ACM regulation of nerve impulse
Myeloid-derived suppressor cells and M2 macrophages in cancer
Oxidative stress in adipocyte dysfunction in type 2 diabetes and metabolic syndrome X
Rb proteins signaling in multiple myeloma
Multiple myeloma (general schema)
SDF-1 axis in endothelial progenitor cell recruitment in healing myocardial infarction
Influence of multiple myeloma cells on bone marrow stromal cells
Immune response_TLR3 and TLR4 induced TICAM1-specific signaling pathway
Development_EGF-induced proliferation of Type C cells in SVZ of adult brain
Signal transduction_PDGF signaling via MAPK cascades
Cell adhesion_PLAU signaling
Regulation of lipid metabolism_Regulation of lipid metabolism by niacin and isoprenaline
Activation of TNF-alpha-dependent pro-tumoral effect in colorectal cancer
Tissue Factor signaling in cancer via PAR1 and PAR2
Immune response_PD-1-induced metabolic changes in T cells
Signal transduction_Soluble CXCL16 signaling
Immune response_Antigen presentation by MHC class I: cross-presentation
Development_HGF-dependent inhibition of TGF-beta-induced EMT
Role of IL-8 in colorectal cancer
Development_Alpha-1 adrenergic receptors signaling via Cyclic AMP
HCV-mediated liver damage and predisposition to HCC progression via p53
Modulation of tumor response to cytotoxic T cells by hypoxia in tumors
Suppression of p53 signaling in multiple myeloma
L-Threonine metabolism
Proteases and EGFR-activated mucin production in airway epithelium in COPD
IGF-1 signaling in multiple myeloma
IgE- and MGF-induced Lyn-mediated production of cytokines and arachidonic acid metabolites in lung mast cells in asthma
Immune response_IL-13 signaling via PI3K-ERK pathway
Muscle contraction_GPCRs in the regulation of smooth muscle tone
Tyrosine metabolism p.2 (melanin)
Eosinophil survival in asthma
Development_Growth factors in regulation of oligodendrocyte progenitor cell proliferation
Inflammatory factors-induced expression of mucins in normal and asthmatic epithelium
Signal transduction_PKA signaling
Inhibition of Calcitriol/ VDR signaling in colorectal cancer
Autophagy_Autophagy
Development_Angiopoietin - Tie2 signaling
Development_Transcriptional regulation of megakaryopoiesis
Role of growth factor receptors transactivation by Hyaluronic acid / CD44 signaling in tumor progression
Immune response_Differentiation of natural regulatory T cells
Role of adhesion of SCLC cells in tumor progression
Anti-apoptotic action of Gastrin in gastric cancer
Transcription_Role of the non-genomic action of Retinoic acid and phosphorylation of Retinoic acid receptors in the initiation of transcription
Action of lithium on synaptic transmission and autophagy
Eosinophil adhesion and transendothelial migration in asthma
Stem cells_Putative pathways of telomerase regulation in glioblastoma stem cells
DNA damage_Inhibition of telomerase activity and cellular senescence
Role of XBP1 protein in multiple myeloma
Development_TGF-beta-induction of EMT via ROS
Regulation of lipid metabolism_Regulation of fatty acid synthesis: NLTP and EHHADH
Th2 cytokine- and TNF-alpha-induced profibrotic response in asthmatic airway fibroblasts/ myofibroblasts
Signal transduction_Additional pathways of NF-kB activation (in the cytoplasm)
Signal transduction_Activation of PKC via G-Protein coupled receptor
IGF signaling in HCC
Signal transduction_Adenosine A2A receptor signaling pathway
Development_Beta adrenergic receptors in brown adipocyte differentiation
IGF-1 signaling in pancreatic cancer
Cigarette smoke components TCDD and Benzo[a]pyrene and receptor AHR signaling in lung epithelial cells
Urea cycle
Higher ESR1 / ESR2 ratio in breast cancer
Statin action on the PI3K/ Akt pathway in COPD
Cell cycle_The metaphase checkpoint
Development_EPO-induced Jak-STAT pathway
Endothelial cell apoptosis in COPD
CHDI_Correlations from Discovery data_Causal network (positive)
Immune response_TLR2 and TLR4 signaling pathways
Calcium-dependent regulation of normal and asthmatic smooth muscle contraction
Apoptosis and survival_Role of PKR in stress-induced apoptosis
IL-6 signaling in breast cancer cells
Probable BMP4-mediated induction of EMT in airway epithelium
Inflammatory response in ischemia-reperfusion injury during myocardial infarction
Development_Schema: Osteogenic and adipogenic differentiation of mesenchymal stem cells
Signal transduction_BMP signaling via ALK-1 and ALK-2 receptors
HCV-dependent transcription regulation leading to HCC
Development_Role of G-CSF in hematopoietic stem cell mobilization
Immune response_Fc epsilon RI pathway: Lyn-mediated cytokine production
Cell adhesion_Plasmin signaling
Th2-cytokine-induced airway epithelium mucous metaplasia in COPD
Development_Growth factors in regulation of oligodendrocyte precursor cell survival
FGFR3 signaling in multiple myeloma
Fibroblast/ myofibroblast proliferation in asthmatic airways
Attenuation of IFN type I signaling in melanoma cells
Immune response_IFN-gamma actions on extracellular matrix and cell differentiation
Immune response_CCL2 signaling
ERBB family and HGF signaling in gastric cancer
Development_Stimulation of differentiation of mouse embryonic fibroblasts into adipocytes by extracellular factors
Development_Positive regulation of STK3/4 (Hippo) pathway and negative regulation of YAP/TAZ function
Glutathione metabolism
Transport_Clathrin-coated vesicle cycle
Signal transduction_Adenosine A2B receptor signaling pathway
Development_Gastrin in differentiation of the gastric mucosa
Development_Noncanonical WNT signaling in cardiac myogenesis
Insulin-like growth factor family signaling in melanoma
wtCFTR and deltaF508-CFTR traffic / Generic schema (normal and CF)
WNT signaling in proliferative-type melanoma cells
Dysregulation of Adiponectin secretion from adipocytes in obesity, type 2 diabetes and metabolic syndrome X
Immune response_The effect of IDO1 on T cell metabolism
TLR and EGFR-induced inflammatory signaling in normal and asthmatic airway epithelium
EGF- and HGF-dependent stimulation of metastasis in gastric cancer
Transcription_CREM signaling in testis
Transition of Monoclonal gammopathy of undetermined significance to active multiple myeloma (schema)
Cell adhesion_Gap junctions
Differences between Langerhans cells and dermal dendritic cells in allergic contact dermatitis
Ubiquitin-proteasome system in Huntington's disease
Inhibition of GSK3 beta by lithium in major depressive disorder
Immune response_Oncostatin M signaling via JAK-Stat
Development_Generation of pancreatic beta-cells from embryonic stem cells (late stages)
Development_Dopamine-induced expression of CNTF in adult neurogenesis
Regulation of Adenylate cyclase and IMPA1 by lithium in major depressive disorder
Amitraz-induced inhibition of Insulin secretion
Signal transduction_Calcium-mediated signaling
Immune response_T cell co-signaling receptors, schema
Immune response_Role of DAP12 receptors in NK cells
Vitamin B3 and NAD+ metabolism
Nociception_Pro-nociceptive action of Nociceptin in spinal cord at low doses
Role of tumor microenvironment in plexiform neurofibroma formation in neurofibromatosis type 1
Atorvastatin in treatment of type 2 diabetes and metabolic syndrome X
TrkB signaling in Huntington's disease
Immune response_HMGB1 release from the cell
Development_ERBB-family signaling
FGF2 signaling in melanoma
Immune response_IL-15 signaling via MAPK and PI3K cascades
Role of FSH and Lutropin in ovarian cancer
MAPK-mediated proliferation of normal and asthmatic smooth muscle cells
Muscle contraction_Regulation of eNOS activity in cardiomyocytes
Translation_Opioid receptors in regulation of translation
KLF6 and regulation of KLF6 alternative splicing in HCC
Development_ERK5 in cell proliferation and neuronal survival
Role of IL-17-producing T cells in allergic contact dermatitis
Transcription_ChREBP regulation pathway
Signal transduction_mTORC1 upstream signaling
Metabolism of L-Proline and derivatives
Immune response_IL-6 signaling pathway via MEK/ERK and PI3K/AKT cascades
Gamma-Secretase regulation of neuronal cell development and function
Transcription_Epigenetic regulation of gene expression
Memory CD8+ T cells in allergic contact dermatitis
Role of glycosphingolipids in inhibition of Insulin signaling
Th2-cytokines-induced mucous metaplasia in asthma
Development_Schema: Embryonal cardiomyogenesis
Androgen receptor activation and downstream signaling in Prostate cancer
Signal transduction_IGF-1 receptor signaling pathway
Tissue factor signaling in lung cancer
Mitochondrial ketone bodies biosynthesis and metabolism
Prolactin/ JAK2 signaling in breast cancer
Huntingtin-depended transcription deregulation in Huntington's Disease
Main growth factor signaling cascades in multiple myeloma cells
Translation_(L)-selenoaminoacids incorporation in proteins during translation
Development_Muscle progenitor cell migration in hypaxial myogenesis
Possible pathway of TGF-beta 1-dependent inhibition of CFTR expression
Regulation of beta-adrenergic receptors signaling in pancreatic cancer
Immune response_TLR2-induced platelet activation
Nociception_Nociceptin receptor signaling
Signal transduction_Angiotensin II/AGTR1 signaling via Notch, Beta-catenin and NF-kB pathways
Glycolysis and gluconeogenesis
L-Methionine metabolism
Cell adhesion_Integrin inside-out signaling in neutrophils
Apoptosis and survival_BAD phosphorylation
Disruption of methionine metabolism in induction and progression of HCC
Development_Growth hormone signaling via PI3K/AKT and MAPK cascades
Estradiol metabolism
Chylomicron dyslipidemia in type 2 diabetes and metabolic syndrome X
Growth factors in regulation of oligodendrocyte precursor cells survival in multiple sclerosis
Immune escape mechanisms in Prostate Cancer
Apoptosis and survival_Apoptotic Activin A signaling
Development_Trophectoderm differentiation
Defective macrophage-mediated bacterial phagocytosis in COPD
Zinc deficiency in Prostate Cancer
HBV-dependent transcription regulation leading to HCC
Role of keratinocytes and Langerhans cells in skin sensitization
Generation of cytotoxic CD8+ T cells in COPD
Immune response_T cell subsets: secreted signals
Putative pathways of hormone action in neurofibromatosis type 1
A shift from oxidative to glycolytic muscle fiber phenotype in quadriceps muscles in COPD
Cell adhesion_Integrin inside-out signaling
Immune response_ICOS signaling pathway in T-helper cell
Neutrophil resistance to apoptosis in COPD and proresolving impact of lipid mediators
Triacylglycerol metabolism p.1
Pro-oncogenic action of Estradiol/ Estrogen receptors in ovarian cancer
DNA damage_DNA-damage-induced responses
Signal transduction_Angiotensin II/ AGTR1 signaling via RhoA and JNK
Tumor metabolic pathways promoting development of Treg cells
Development_ACM2 and ACM4 activation of ERK
Signal transduction_AKT signaling
Immune response_Antimicrobial actions of IFN-gamma
Apoptosis and survival_Anti-apoptotic action of Gastrin
Signal transduction_Modulation of calcium and potassium channels by Adenosine A1 receptor
FGF signaling in Prostate Cancer
Apoptosis and survival_TNFR1 signaling pathway
Immune response_IL-9 signaling pathway
Tricarbonic acid cycle
CHDI_Correlations from Replication data_Causal network (positive correlations)
Hedgehog signaling in prostate cancer
Role of fibroblasts and keratinocytes in the elicitation phase of allergic contact dermatitis
G-protein signaling_Ras family GTPases in kinase cascades
Cell adhesion_Endothelial cell contacts by junctional mechanisms
Cell adhesion_Classical cadherin-mediated cell adhesion
Cell cycle_Transition and termination of DNA replication
Immune response_IL-13 signaling via JAK-STAT
IGF signaling in lung cancer
K-RAS signaling in pancreatic cancer
Role of CD8+ Tc1 cells in COPD
Regulation of metabolism_Triiodothyronine and Thyroxine signaling
Immune response_CRTH2 signaling in Th2 cells
Release of pro-inflammatory factors and proteases by alveolar macrophages in asthma
DNA damage_ATM/ATR regulation of G1/S checkpoint
Leptin signaling in colorectal cancer
Glucocorticoid-induced elevation of intraocular pressure as glaucoma risk factor
Renin-Angiotensin-Aldosterone System
Regulation of microRNAs in colorectal cancer
Heparan sulfate/heparin metabolism
Activation of osteoclast differentiation in bone lesions formation in multiple myeloma
G-protein signaling_G-Protein alpha-i signaling cascades
Development_Generation of pancreatic beta-cells from induced pluripotent stem cells
Brca1 in ovarian cancer
HCV-dependent cytoplasmic signaling leading to HCC
Glomerular filtration and renal reabsorption of bile acids / Rodent version
HCV-dependent regulation of membrane receptors signaling in HCC
Transport_Rab-9 regulation pathway
Sitagliptin in treatment of type 2 diabetes and metabolic syndrome X
Immune response_IL-18 signaling
Propionate metabolism p.2
Neuroprotective action of lithium
Vascular endothelial cell damage in SLE
Cell adhesion_Integrin-mediated cell adhesion and migration
Immune response_Antigen presentation by MHC class II
Role of alpha-6/beta-4 integrins in carcinoma progression
Development_Membrane-bound ESR1: interaction with growth factors signaling
Role of cell adhesion molecules in progression of pancreatic cancer
Role of TNF-alpha, IL-1beta and IL-6 in development of obesity and type 2 diabetes in liver
Signal transduction_Angiotensin II/ AGTR1 signaling via p38, ERK and PI3K
Signal transduction_Non-canonical WNT5A signaling
SLE genetic marker-specific pathways in T cells
Niacin-HDL metabolism
Cytoskeleton remodeling_Regulation of actin cytoskeleton nucleation and polymerization by Rho GTPases
Regulation of GSK3 beta in bipolar disorder
Development_TGF-beta-dependent induction of EMT via RhoA, PI3K and ILK
Impaired inhibition of Th17 cell differentiation by IFN-beta in multiple sclerosis
Neurophysiological process_Role of CDK5 in presynaptic signaling
Development_Role of CNTF and LIF in regulation of oligodendrocyte development
Immune response_IFN-gamma actions on blood cells
Development_Mu-type opioid receptor regulation of proliferation
Release of pro-inflammatory mediators and elastolytic enzymes by alveolar macrophages in COPD
GLP-1 in inhibition of insulin secretion in type 2 diabetes
Glucocorticoid- and LABA-mediated inhibition of pro-inflammatory signaling in airway fibroblasts/myofibroblasts
Regulation of Beta-catenin activity in melanoma
Dysregulation of germinal center response in SLE
Renal tubulointerstitial injury in Lupus Nephritis
NF-AT signaling in cardiac hypertrophy
G-protein signaling_Rap1B regulation pathway
Mechanism of Pioglitazone/Glimepiride and Rosiglitazone/Glimepiride cooperative action in Diabetes mellitus, Type 2
Immune response_PGE2 in immune and neuroendocrine system interactions
Development_Hedgehog signaling
Canonical Leptin pathways in breast cancer
Transport_Alpha-2 adrenergic receptor regulation of ion channels
Immune response_Role of DPP4 (CD26) in immune regulation
Cholesterol Biosynthesis
Apoptosis and survival_nAChR in apoptosis inhibition and cell cycle progression
Histone deacetylases in Prostate Cancer
Immune response_CD137 signaling in immune cell
Common mechanisms of Th17 cell migration
Immune response_C3a signaling
Neuroendocrine transdifferentiation in Prostate Cancer
Role of microRNAs in cell migration, survival and angiogenesis in colorectal cancer
Regulation of lipid metabolism_RXR-dependent regulation of lipid metabolism via PPAR, RAR and VDR
Role of histone modificators in progression of multiple myeloma
Inhibition of Ephrin receptors in colorectal cancer
Immune response_Mast cell proliferation, differentiation and survival
Inhibition of mast cell functions by Fc gamma RII beta in asthma
Neurophysiological process_Mu-type opioid receptor-mediated analgesia
Immune response_BAFF-induced non-canonical NF-kB signaling
DNA damage_Brca1 as a transcription regulator
Production of arachidonic acid derivatives by mast cells in asthma
Immune response_NF-AT signaling and leukocyte interactions
Mechanisms of drug resistance in multiple myeloma
Bacterial infections in CF airways
IgE- and MGF-induced Fyn-mediated activation of lung mast cells in asthma
Immune response_Bacterial infections in normal airways
Role and regulation of Prostaglandin E2 in gastric cancer
Breakdown of CD4+ T cell peripheral tolerance in type 1 diabetes mellitus
Demyelination in multiple sclerosis
Cytoskeleton remodeling_Integrin outside-in signaling
Transport_Macropinocytosis
Arachidonic acid metabolites production in alveolar macrophages in asthma
Putative glucocorticoid- and LABA-mediated inhibition of pro-fibrotic signaling in airway fibroblasts/myofibroblasts
Role of IL-2 in the enhancement of NK cell cytotoxicity in multiple sclerosis
Autocrine production of eosinophil pro-survival cytokines in asthma
Neutrophil adhesion and transendothelial migration in asthma
Fibroblast differentiation to myofibroblasts in asthmatic airways
Development_Dopamine-induced transactivation of EGFR in SVZ neural stem cells
IL-1 beta-dependent CFTR expression
Regulation of lipid metabolism_FXR-dependent negative-feedback regulation of bile acids concentration
Mechanisms of K-RAS addiction in lung cancer cells
Cigarette smoke-induced proliferation, metaplasia and survival of airway epithelial cells
Development_GM-CSF signaling
Development_EDNRB signaling
Mucin expression in CF airways
Chemotaxis_CXCR3-A signaling
Role of microRNAs in cell proliferation in colorectal cancer
Development_Positive regulation of WNT/Beta-catenin signaling in the nucleus
Regulation of lipid metabolism_Insulin regulation of fatty acid metabolism
Hypertrophy of asthmatic airway smooth muscle cells
Tyrosine metabolism p.1 (dopamine)
DNA damage_ATM/ATR regulation of G2/M checkpoint: cytoplasmic signaling
Immune response_IFN-gamma signaling via MAPK
Immune response_BAFF-induced signaling
microRNA in Prostate Cancer
Putative pathways of n-3 and n-6 fatty acids in obesity and type 2 diabetes
Immune response_NF-AT in immune response
Some pathways of EMT in cancer cells
Hypoxia-induced EMT in cancer and fibrosis
EML4/ALK fusion protein in nonsmoking-related lung cancer
Th2 cytokine-induced alternative activation of alveolar macrophages in asthma
Selective Insulin resistance in type 2 diabetes in liver
The role of KEAP1/NRF2 pathway in skin sensitization
Cytoskeleton remodeling_Reverse signaling by Ephrin-B
Signal transduction_ERK1/2 signaling pathway
Development_Role of Ceramide 1-phosphate, Sphingosine 1-phosphate and Complement cascade in hematopoietic stem cell homing
Upregulation of IL-8 expression in colorectal cancer
Hedgehog signaling in pancreatic cancer
Development_EGFR signaling pathway
Gamma-aminobutyrate (GABA) biosynthesis and metabolism
Development_Endothelin-1/EDNRA signaling
CoA biosynthesis
Nicotine signaling in cholinergic neurons
Immune response_Antiviral actions of Interferons
p53 signaling in Prostate Cancer
IGF family, invasion and metastasis in colorectal cancer
Role of GSK3 beta in cardioprotection against myocardial infarction
Interaction of deficient alpha-MSH signaling with TNF-alpha in melanoma
IL-2 as a growth factor for T cells in multiple sclerosis
Chemotaxis_CCL19- and CCL21-mediated chemotaxis
Blood coagulation_Platelet microparticle generation
ENaC regulation in normal and CF airways
Notch signaling in breast cancer
Role of IL-23/ T17 pathogenic axis in psoriasis
Riboflavin metabolism
HBV regulation of DNA repair and apoptosis leading to HCC
IL-6 signaling in tumor-associated monocytes/macrophages in breast cancer
Immune response _Sialic-acid receptors (Siglecs) signaling
Cell cycle_Nucleocytoplasmic transport of CDK/Cyclins
Immune response_IFN-alpha/beta signaling via MAPKs
Signal transduction_Erk Interactions: Inhibition of Erk
Development_S1P1 receptor signaling via beta-arrestin
Th2 cell migration in asthma
Apoptosis and survival_Role of CDK5 in neuronal death and survival
Immune response_IL-11 signaling via JAK/STAT
Development_Histone acetylation in embryonic stem cells
Microsatellite instability in colorectal cancer
G-protein signaling_G-Protein beta/gamma signaling cascades
Role of IFN-beta in inhibition of Th1 cell differentiation in multiple sclerosis
Development_VEGF signaling via VEGFR2 - generic cascades
Immune response_IFN-gamma signaling via JAK/STAT and PLC-gamma
GTP metabolism
Membrane-bound ESR1: interaction with G-proteins signaling
Blood coagulation_GPVI-dependent platelet activation
Eosinophil granule protein release in asthma
Role of ER stress in obesity and type 2 diabetes
Development_Differentiation of white adipocytes
Arachidonic acid production
L-Phenylalanine metabolism
Immune response_IFN-alpha/beta signaling via PI3K and NF-kB pathways
Cell adhesion_Alpha-4 integrins in cell migration and adhesion
Estrone metabolism
Immune response_TLR ligands
Role of Tissue factor in cancer independent of coagulation protease signaling
Keratan sulfate metabolism p.1
Beta-alanine metabolism
Development_Growth hormone signaling via STATs and PLC/IP3
Anti-apoptotic action of Gastrin in pancreatic cancer
Cell cycle_ESR1 regulation of G1/S transition
Development_WNT and Notch signaling in early cardiac myogenesis
Basophil migration in asthma
Aberrant B-Raf signaling in melanoma progression
Apoptosis and survival_NO synthesis and signaling
Immune response_CD28 signaling
Immune response_Immunological synapse formation
Development_Fetal brown fat cell differentiation
Apoptosis and survival_DNA-damage-induced apoptosis
HSP22 and BAG-3-dependend macroautophagy in Huntington's disease
Role of GITR in skin sensitization
Gamma-secretase proteolytic targets
Apoptosis and survival_Endoplasmic reticulum stress response pathway
Signal transduction_Leptin signaling in non-neuronal cells
Immune response_IL-6-induced acute-phase response in hepatocytes
Th17 cytokines in COPD
Immune response_IL-22 signaling pathway
Cigarette smoke-induced inflammatory signaling in airway epithelial cells
Influence of low doses of Arsenite on Glucose stimulated Insulin secretion in pancreatic cells
Role of IL-8 in melanoma
iNKT cell-keratinocyte interactions in allergic contact dermatitis
G-protein signaling_Regulation of RAC1 activity
Immune response_IL-12 and IL-18-induced IFN-gamma production
Cytoskeleton remodeling_Substance P mediated membrane blebbing
wtCFTR and deltaF508 traffic / Late endosome and lysosome (normal and CF)
Intercellular relations in asthma (general schema)
c-Myc in multiple myeloma
Development_Non-genomic action of Retinoic acid in cell differentiation
Development_Cytokine-mediated regulation of megakaryopoiesis
Regulation of metabolism_Insulin regulation of glycogen metabolism
Transcription_CoREST complex-mediated epigenetic gene silencing
Glycogen metabolism
Down-regulation of mast cell functions through ITIM-containing inhibitory receptors in asthma
Cholehepatic circulation of bile acids / Rodent version
Deregulation of PSD-95-dependent signaling in Huntington's disease
Immune response_IL-7 signaling in T lymphocytes
Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2
Role of red blood cell adhesion to endothelium in vaso-occlusion in Sickle cell disease
Development_Prolactin receptor signaling
Role of integrins in eosinophil degranulation in asthma
Cytoskeleton remodeling_Regulation of actin cytoskeleton organization by the kinase effectors of Rho GTPases
Development_MAG, Reticulon 4 and OMgp in inhibition of neurite outgrowth
Apoptosis and survival_Anti-apoptotic action of membrane-bound ESR1
Cortisol biosynthesis from Cholesterol
Aldosterone biosynthesis and metabolism
Defective efferocytosis in COPD
Neutrophil chemotaxis in asthma
Development_SDF-1 signaling in hematopoietic stem cell homing
Cytoskeleton remodeling_ACM3 and ACM4 in keratinocyte migration
HDL dyslipidemia in type 2 diabetes and metabolic syndrome X
Development_FGF10 in development of subcutaneous white adipose tissue in embryogenesis
Transcription_Transcription factor Tubby signaling pathways
DeltaF508-CFTR traffic / ER-to-Golgi in CF
DNA damage_Role of SUMO in p53 regulation
LRRK2 in neuronal apoptosis in Parkinson's disease
Transition of Smoldering multiple myeloma to active multiple myeloma (schema)
G-protein signaling_Rap2A regulation pathway
wtCFTR traffic / ER-to-Golgi (normal)
Regulation of lipid metabolism_G-alpha(q) regulation of lipid metabolism
Neurophysiological process_Constitutive and activity-dependent synaptic AMPA receptor delivery
Inhibition of apoptosis in pancreatic cancer
Transcription_Role of VDR in regulation of genes involved in osteoporosis
Transport_Regulation of ATP-binding transporters by Retinoic acid and orphan nuclear receptor PXR
Keratan sulfate metabolism p.2
Role of iNKT and B cells in T cell recruitment in allergic contact dermatitis
VLDL, LDL dyslipidemia in type 2 diabetes and metabolic syndrome X
Immune response_Differentiation and clonal expansion of CD8+ T cells
Deregulation of Ca2+-dependent neuronal cell survival in Huntington's disease
IGF family signaling in colorectal cancer
DNA damage_p53 activation by DNA damage
Regulation of lipid metabolism_Regulation of acetyl-CoA carboxylase 1 activity
FGF2 in multiple myeloma
Beta-adrenergic-dependent CFTR expression
Stem cells_CD30 signaling in transformed embryonic stem cells
Development_FGF2-induced self-renewal of adult neural stem cells
Reproduction_Progesterone-mediated oocyte maturation
G-protein signaling_Rap1A regulation pathway
IFN-gamma and Th2 cytokines-induced inflammatory signaling in normal and asthmatic airway epithelium
Stem cells_Pancreatic cancer stem cells in tumor metastasis
Recurrent gene fusions in Prostate Cancer
Enterohepatic circulation of bile acids / Rodent version
Cell adhesion_IL-8 family-dependent cell migration and adhesion
Immune response_IL-1 signaling pathway
Immune response_IL-10 signaling pathway
Transport_Intracellular cholesterol transport
Development_Oxytocin receptor signaling
Pro-tumoral TNF-alpha signaling in melanoma
Apoptosis and survival_Phosphorylation and acetylation in TNF-alpha-induced NF-kB signaling
Apoptosis and survival_Phosphorylation in TNF-alpha-induced NF-kB signaling
DKK1 signaling in multiple myeloma
Anti-apoptotic pathways in endoplasmic reticulum stress response in multiple myeloma
Signal transduction_BMP signaling via ALK-4 and TGF-beta receptor type I
Schema: Initiation of T cell recruitment in allergic contact dermatitis
Regulation of lipid metabolism_Regulation of fatty acid synthase activity in hepatocytes
Immune response_ETV3 affect on CSF1-promoted macrophage differentiation
Transcription_PPAR Pathway
Sulfur metabolism
Inhibition of GTPase prenylation by statins in asthma and COPD
Transport_HDL-mediated reverse cholesterol transport
CFTR-dependent regulation of ion channels in CF
Oxidative stress_Activation of NOX1, NOX5, DUOX1 and DUOX2 NADPH Oxidases
Apoptosis and survival_Lymphotoxin-beta receptor signaling
MAPK-independent proliferation of normal and asthmatic smooth muscle cells
Eosinophil chemotaxis in asthma
Neurophysiological process_Activity-dependent synaptic AMPA receptor removal
Polyamine metabolism
Regulation of degradation of wtCFTR
HBV mediates angiogenesis in HCC
CCL2 in Prostate Cancer
Endothelin-1- and TNF-alpha-induced inflammatory response in asthmatic airway fibroblasts
wtCFTR and deltaF508-CFTR traffic / Clathrin coated vesicles formation (normal and CF)
Protein folding and maturation_Insulin processing
Nicotine signaling in dopaminergic neurons, Pt. 2 - axon terminal
Chemotaxis_CCL16-, CCL20-, CXCL16- and CCL25-mediated cell migration
Cytoskeleton remodeling_Hyaluronic acid/ CD44 signaling pathways
Regulation of metabolism_Role of Adiponectin in regulation of metabolism
Nicotine / nAChR alpha-7 signaling in NSCLC
Development_WNT/Beta-catenin signaling pathway. Signalosome
Neurophysiological process_Constitutive and regulated NMDA receptor trafficking
Development_Role of HGF in hematopoietic stem cell mobilization
Multiple sclerosis (general schema)
Cell cycle_Chromosome condensation in prometaphase
HCV-dependent regulation of RNA polymerases leading to HCC
DNA damage_ATM-dependent double-strand break foci
Immune response_T regulatory cell-mediated modulation of antigen-presenting cell functions
Influence of smoking on activation of EGFR signaling in lung cancer cells
Neurophysiological process_Melatonin signaling
Cell adhesion_Tight junctions
Development_S1P1 signaling pathway
Inhibition of remyelination in multiple sclerosis: regulation of cytoskeleton proteins
Cell adhesion_Ephrin signaling
LKB1 signaling pathway in lung cancer cells
Mitochondrial unsaturated fatty acid beta-oxidation
DNA damage_ATM/ATR regulation of G2/M checkpoint: nuclear signaling
Mechanisms of resistance to EGFR inhibitors in lung cancer
Role of free fatty acids in obesity and type 2 diabetes
Development_Negative regulation of WNT/Beta-catenin signaling in the nucleus
wtCFTR traffic / Sorting endosome formation (normal)
Translation_Role of Retinoic acid signaling in the initiation of translation
Taurine and hypotaurine metabolism
Microsatellite instability in gastric cancer
Role of Huntingtin in regulation of BDNF in Huntington's disease
Development_H3K9 demethylases in pluripotency maintenance of stem cells
Development_Mu-type opioid receptor signaling via Beta-arrestin
Origin of Langerhans cells in the steady-state and under inflammatory conditions
LRRK2 and immune function in Parkinson's disease
Immune response_Sublytic effects of membrane attack complex
Immune response_Fc epsilon RI pathway: calcium-dependent signaling
Glycine and L-Serine metabolism
Development_G-protein-mediated regulation of MAPK-ERK signaling
Immune response_Inhibitory action of Lipoxins on pro-inflammatory TNF-alpha signaling
Transcription_Hypoxia- and receptor-mediated HIF-1 activation
EGFR signaling in Prostate Cancer
Signal transduction_Intracellular calcium increase
FGF signaling in pancreatic cancer
Immune response_CD16 signaling in NK cells
Transcription_Negative regulation of HIF1A function
Stem cells_MMP-14-induced COX-2 expression in glioblastoma stem cells
Proteolysis_Putative ubiquitin pathway
Cytoskeleton remodeling_ESR1 action on cytoskeleton remodeling and cell migration
G-protein signaling_Cross-talk between Ras-family GTPases
Apoptosis and survival_NO signaling in apoptosis
Cytoskeleton remodeling_Neurofilaments in axon growth and synapses
Regulation of metabolism_Insulin signaling: generic cascades
Development_Beta-adrenergic receptor-induced regulation of ERK
Th9 cells in asthma
Immune response_KLRK1 (NKG2D) signaling pathway
Development_PIP3 signaling in cardiac myocytes
Canonical Notch signaling pathway in colorectal cancer
Role of proinflammatory cytokines in activation of p53 in major depressive disorder
Phospholipid metabolism p.2
Neurophysiological process_PGE2-induced pain processing
Neurophysiological process_Circadian rhythm
Glomerular injury in Lupus Nephritis
Protein folding and maturation_Angiotensin system maturation
Oxidative stress_Role of IL-8 signaling pathway in respiratory burst
Development_Adiponectin signaling
Cell adhesion_Endothelial cell contacts by non-junctional mechanisms
Development_Schema: SMAD-dependent TGF-beta family signaling in embryonic stem cells
Apoptosis and survival_NO signaling in survival
Immune response_IL-27 signaling pathway
Axonal degeneration in multiple sclerosis
PDE4 regulation of cyto/chemokine expression in arthritis
Transcription_CREB signaling pathway
Neurophysiological process_HTR2A signaling in the nervous system
Development_G-CSF signaling
Histidine-glutamate-glutamine metabolism
Immune response_IL-2 signaling via JAK/ STAT
A proinflammatory phenotype of senescent alveolar epithelial cells in COPD
G-protein signaling_TC21 regulation pathway
Dual role of BMP signaling in gastric cancer
Immune response_IL-2 signaling via ERK, PI3K, and PLC-gamma
Development_Thromboxane A2 signaling pathway
Cell adhesion_Role of tetraspanins in the integrin-mediated cell adhesion
TGF-beta signaling via microRNA in breast cancer
PI3K signaling in gastric cancer
Signal transduction_Amino acid-dependent mTORC1 activation
Immune response_Distinct metabolic pathways in naive and effector CD8+ T cells
Ubiquinone metabolism
L-Tryptophan metabolism (part 2)
Neurophysiological process_GABA-B receptor signaling at postsynaptic sides of synapses
Downregulation of MITF in melanoma
Development_S1P2 and S1P3 receptors in cell proliferation and differentiation
CD8+ Tc1 cells in allergic contact dermatitis
Immune response_Histamine signaling in dendritic cells
EGFR family signaling in pancreatic cancer
Cell adhesion_Integrin inside-out signaling in T cells
Development_FGF-family signaling
Development_Positive regulation of WNT/Beta-catenin signaling in the cytoplasm
Transport_Induction of Macropinocytosis
Notch signaling in oligodendrocyte precursor cell differentiation in multiple sclerosis
Inhibition of TGF-beta 1 signaling in early colorectal cancer
Desensitization of Beta-2 adrenergic receptor signaling and reduction of relaxation
DeltaF508-CFTR traffic / Sorting endosome formation in CF
Stem cells_Cytotoxic effect of temozolomide on glioblastoma cells
Neurophysiological process_Sweet taste signaling
Th2-cytokines and IFN-mediated regulation of airway smooth muscle contraction
SLE genetic marker-specific pathways in B cells
Aryl hydrocarbon receptor signaling
Neurophysiological process_Long-term depression in cerebellum
Proinflammatory cytokine production by Th17 cells in asthma
Apoptosis and survival_NGF/ TrkA PI3K-mediated signaling
Cell cycle_Regulation of G1/S transition (part 2)
Mitogenic action of Estradiol / ESR1 (nuclear) in breast cancer
Neurophysiological process_Bitter taste signaling
Putative pathways of activation of classical complement system in major depressive disorder
Pro-oncogenic action of Androgen receptor in ovarian cancer
Role of Th17 cells in asthma
Immune response_IL-16 signaling pathway
Ganglioside Metabolism p1
NRF2 regulation of oxidative stress response
Oxidative stress_Role of ASK1 under oxidative stress
Mitochondrial beta-oxidation of long-chain saturated fatty acids
Leucine, isoleucine and valine metabolism.p.2
Chemotaxis_SDF-1/ CXCR4-induced chemotaxis of immune cells
Immune response_M-CSF-receptor signaling pathway
Immune response_Platelet activating factor/ PTAFR pathway signaling
Development_WNT/Beta-catenin signaling in the cytoplasm
Immune response_Delta-type opioid receptor signaling in T-cells
Cholesterol and Sphingolipid transport / Recycling to plasma membrane in lung (normal and CF)
Role of Neuregulin 1 and Thymosin beta-4 in myocardium regeneration after infarction
Stem cells_Notch signaling in medulloblastoma stem cells
Proteolysis_Putative SUMO-1 pathway
Vitamin D2 (ergocalciferol) metabolism
Cigarette smoke-mediated attenuation of antibacterial and antivirus immune response
Regulation of Beta-catenin activity in colorectal cancer
Airway smooth muscle contraction in asthma
Protein folding and maturation_POMC processing
Development_Osteopontin signaling in osteoclasts
Development_G-CSF-induced myeloid differentiation
Fatty Acid Omega Oxidation
T regulatory cells in asthma
Role of CNTF and LIF in regulation of oligodendrocyte development in multiple sclerosis
Inter-cellular relations in COPD (general schema)
Transport_Aldosterone-mediated regulation of ENaC sodium transport
DNA damage_Role of Brca1 and Brca2 in DNA repair
Activation of TGF-beta signaling in advanced colorectal cancer
Fructose metabolism
NETosis in SLE
Development_FGF and BMP signaling in early embryonic hepatogenesis
Influence of low doses of Arsenite on glucose uptake in adipocytes
Immune response_IL-23 signaling pathway
Alternative complement cascade disruption in age-related macular degeneration
Aberrant production of IL-2 and IL-17 in SLE T cells
Putative role of Estrogen receptor and Androgen receptor signaling in progression of lung cancer
Immune response_TLR5, TLR7, TLR8 and TLR9 signaling pathways
Immune response_IL-33 signaling pathway
Phospholipid metabolism p.1
Role of B cells in SLE
Development_Transcription regulation of granulocyte development
Neurophysiological process_Glucose-excited neurons of ventromedial nucleus (rodent model)
Immunological synapse between dendritic and CD8+ T cells in allergic contact dermatitis
Interleukins-induced inflammatory signaling in normal and asthmatic airway epithelium
Stem cells_Role of ion channels in glioblastoma cell invasion
Protein folding and maturation_Bradykinin / Kallidin maturation
Renal secretion of inorganic electrolytes
Mitochondrial dysfunction in neurodegenerative diseases
HCV-mediated liver damage and predisposition to HCC via cell stress
Oxidative stress_ROS-mediated MAPK activation via canonical pathways
Antioxidant effects of statins in COPD
Transcription_Effect of Folic acid on genome stability
Deficient alpha-MSH signaling in melanoma
G-protein signaling_N-RAS regulation pathway
Development_EGFR signaling via small GTPases
Aflatoxin B1-dependent induction of HCC
Development_Role of PKR1 and ILK in cardiac progenitor cells
LRRK2 in neurons in Parkinson's disease
Coronavirus disease-19
Immune response_Fc epsilon RI pathway: signaling through Fyn and PI3K
Nicotine / Beta-adrenergic signaling in lung cancer
Regulation of CFTR gating (normal and CF)
G-protein signaling_RhoA regulation pathway
Development_CNTF receptor signaling
Oxidative stress_ROS-mediated activation of MAPK via inhibition of phosphatases
Apoptosis and survival_Cytoplasmic/mitochondrial transport of proapoptotic proteins Bid, Bmf and Bim
Pentose phosphate pathway
Vitamin B6 metabolism
Development_WNT/Beta-catenin signaling in the nucleus
Development_Gastrin in cell growth and proliferation
Regulation of intrinsic membrane properties and excitability of striatonigral medium spiny neurons in Huntington's disease
Aminoglycoside- and cisplatin-induced hair cell death
Development_Regulation of telomere length and cellular immortalization
G-protein signaling_S1P2 receptor signaling pathway
Altered Ca2+ handling in heart failure
IL-6 signaling pathway in lung cancer
TNF-alpha and IL-1 beta induce hyperglycemia in obesity and type 2 diabetes in adipocytes
Mechanisms of CAM-DR in multiple myeloma
Galactose metabolism
n-3 Polyunsaturated fatty acid biosynthesis
CHDI_Correlations from Replication data_Cytoskeleton and adhesion module
Propionate metabolism p.1
PR action in breast cancer: stimulation of cell growth and proliferation
G-protein signaling_G-Protein alpha-s signaling cascades
TNF-alpha and IL-1 beta-mediated regulation of contraction and secretion of inflammatory factors in normal and asthmatic airway smooth muscle
Ovarian cancer (main signaling cascades)
Unsaturated fatty acid biosynthesis
Development_Negative feedback regulation of WNT/Beta-catenin signaling
Cholesterol and Sphingolipid transport / Transport from Golgi and ER to the apical membrane (normal and CF)
G-protein signaling_RAC1 in cellular process
Development_Beta-adrenergic receptors transactivation of EGFR
A shift in alveolar macrophage phenotype in COPD
Immune response_Regulation of T cell function by CTLA-4
Metabolism in pancreatic cancer cells
G-protein signaling_G-Protein alpha-12 signaling pathway
Role of type 2 innate lymphoid cells in airway allergic inflammation and tissue repair
Role of Endothelin-1 in inflammation and vasoconstriction in Sickle cell disease
Impaired macrophage phagocytic function in asthma
Substance P-mediated inflammation and pain in Sickle cell disease
Translation_Regulation of EIF2 activity
Role of type 2 innate lymphoid cells in asthma
Immune response_IL-11 signaling pathway via MEK/ERK and PI3K/AKT cascades
ErbB2-induced breast cancer cell invasion
Ligand-independent activation of Androgen receptor in Prostate Cancer
Immune response_Gastrin in inflammatory response
Production of reactive oxygen species and arachidonic acid metabolites by neutrophils in asthma
Lipoprotein metabolism
Regulation of degradation of deltaF508-CFTR in CF
De novo IMP biosynthesis
Activation of Notch signaling in breast cancer
Apoptosis and survival_Ubiquitination and phosphorylation in TNF-alpha-induced NF-kB signaling
Cooperative action of IFN-gamma and TNF-alpha on astrocytes in multiple sclerosis
CAR-mediated direct regulation of xenobiotic metabolizing enzymes / Rodent version
Apoptosis and survival_Ceramides signaling pathway
Neurophysiological process_Netrin-1 in regulation of axon guidance
DNA damage_Classical NHEJ mechanism of DSBs repair
The role of UV radiation in melanoma development
CAR-mediated direct regulation of xenobiotic metabolizing enzymes / Human version
Development_WNT/Beta-catenin and NOTCH in induction of osteogenesis
Leukotriene 4 biosynthesis and metabolism
Neurophysiological process_ACM1 and ACM2 in neuronal membrane polarization
Androstenedione and testosterone biosynthesis and metabolism p.3
DNA damage_Nucleotide excision repair
Development_Growth hormone-releasing hormone (GH-RH) signaling
Immune response_Neurotensin-induced activation of IL-8 in colonocytes
Neurophysiological process_Glucose-inhibited neurons of ventromedial and arcuate nuclei (rodent model)
Maturation and migration of dendritic cells in skin sensitization
Oxidative phosphorylation
Cytoskeleton remodeling_Role of PKA in cytoskeleton reorganisation
Inhibition of neutrophil migration by proresolving lipid mediators in COPD
Role of TNF-alpha in type 2 diabetes in skeletal muscle cells
Immune response_PIP3 signaling in B lymphocytes
Development_NOTCH in inhibition of WNT/Beta-catenin-induced osteogenesis
TNF-alpha, IL-1 beta induce dyslipidemia and inflammation in obesity and type 2 diabetes in adipocytes
Angiotensin II Signaling in Cardiac Hypertrophy
Aspartate and asparagine metabolism
Vitamin D3 metabolic C-23 and C-24 pathways
Neurophysiological process_HTR1A receptor signaling in neuronal cells
Effect of H. pylori infection on gastric epithelial cells motility
Leucine, isoleucine and valine metabolism
ESR1 (membrane) 36 kDa isoform signaling in breast cancer
NF-kB-, AP-1- and MAPKs-mediated proinflammatory cytokine production by eosinophils in asthma
Immune response_Substance P-stimulated expression of proinflammatory cytokines via MAPKs
Development_S1P3 receptor signaling pathway
Environmental factors-induced inflammatory signaling in normal and asthmatic airway epithelium
Apoptosis and survival_TNF-alpha-induced Caspase-8 signaling
Regulation of immune cell differentiation by Notch signaling
Signal transduction_HTR2A signaling outside the nervous system
Thiamine metabolism
Transport_cAMP/ Ca(2+)-dependent Insulin secretion
Proliferative action of Gastrin in pancreatic cancer
Development_Flt3 signaling
Role of mevalonate pathway in multiple myeloma
Ganglioside Metabolism p2
Chemotaxis_C5a-induced chemotaxis
Apoptosis and survival_Inhibition of ROS-induced apoptosis by 17beta-estradiol
Heme metabolism
Regulation of relaxation of airway smooth muscle cells
Retinal ganglion cell damage in glaucoma
Development_Activation of ERK by Alpha-1 adrenergic receptors
Proinflammatory mediators production and activation of basophils in asthma
Immune response_PGE2 signaling in immune response
L-Alanine and L-cysteine metabolism
Dual function of Treg cells in cancer development
Signal transduction_PTEN pathway
Neurogenesis_NGF/ TrkA MAPK-mediated signaling
Immune response_Histamine H1 receptor signaling in immune response
Vitamin B7 (biotin) metabolism
Mechanisms of deltaF508 CFTR activation by S-nitrosoglutathione
Mitogenic action of ESR1 (membrane) in breast cancer
Immune response_PGE2 common pathways
Renal secretion of drugs / Rodent version
Transport_GPR40 signaling pathway in beta cells
L-Arginine metabolism
Signal transduction_Adenosine A3 receptor signaling pathway
Nicotine signaling in dopaminergic neurons, Pt. 1 - cell body
K-RAS signaling in lung cancer
Glucocorticoids-mediated inhibition of pro-constrictory and pro-inflammatory signaling in airway smooth muscle cells
Transcription_N-CoR/ SMRT complex-mediated epigenetic gene silencing
Neutrophil-derived granule proteins and cytokines in asthma
CHDI_DEGs from Replication data_Causal network
Vitamin E (alfa-tocopherol) metabolism
Signal transduction_S1P4 receptor and S1P5 receptor signaling
Immune response_Production and main functions of biologically active leukotrienes and Lipoxin A4
Immune response_Lectin induced complement pathway
Pro-inflammatory action of Gastrin in gastric cancer
Immune response_Function of MEF2 in T lymphocytes
Apoptosis and survival_HTR1A signaling
HBV-dependent NF-kB and PI3K/AKT pathways leading to HCC
Cortisone biosynthesis and metabolism
Neurophysiological process_GABAergic neurotransmission
Anti-apoptotic action of ErbB2 in breast cancer
Development_Beta-adrenergic receptors signaling via Cyclic AMP
Epithelial cell anoikis in COPD
Mechanism of gemcitabine action in pancreatic cancer
G-protein signaling_Proinsulin C-peptide signaling
Immune response_T cell subsets: cell surface markers
Phosphatidylinositol metabolism
Effect of H. pylori infection on apoptosis in gastric epithelial cells
Development_Role of growth factors in the maintenance of embryonic stem cell pluripotency
Development_Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
Translation_Translation regulation by Alpha-1 adrenergic receptors
Immune response_Alternative complement pathway
Cell cycle_Influence of Ras and Rho proteins on G1/S Transition
Proliferative action of Gastrin in gastric cancer
Signal transduction_Non-apoptotic FasR(CD95) signaling
Development_FGFR signaling pathway
Androstenedione and testosterone biosynthesis and metabolism p.1
Translation_Regulation of EIF4F activity
Immune response_Antigen presentation by MHC class I, classical pathway
Regulation of AKT(PKB)/ GSK3 beta cascade in bipolar disorder
Chemotaxis_CCL2-induced chemotaxis
Development_Keratinocyte differentiation
Muscle contraction_ACM regulation of smooth muscle contraction
Signal transduction_Somatostatin signaling via SSTR1, SSTR3, SSTR4, and SSTR5
Nicotine metabolism in liver
Mitogenic action of ErbB2 in breast cancer
Immune response_IFN-gamma signaling via PI3K and NF-kB
Metabolism of L-cysteine, D-cysteine and L-cystine
GTP-XTP metabolism
Induction of mucin secretion in airway goblet cells by purinergic receptors
CCR7 signaling pathways in dendritic cells in allergic contact dermatitis
Regulation of intrinsic membrane properties and excitability of striatopallidal medium spiny neurons in Huntington's disease
Lysophospholipid mediators-induced inflammatory signaling in normal and asthmatic airway epithelium
Immune response_CCR5 signaling in macrophages and T lymphocytes
Oxidative stress_Activation of NADPH oxidase
Signal transduction_Production and main functions of biologically active prostaglandins and Thromboxane A2
Cigarette smoke-induced oxidative stress and apoptosis in airway epithelial cells
Aminosugar metabolism
Apoptosis and survival_TNF-alpha-induced ROS-dependent Caspase-3 signaling
Immune response_iC3b-induced phagocytosis via alpha-M/beta-2 integrin
n-6 Polyunsaturated fatty acid biosynthesis
Neolacto-series GSL Metabolism p.2
Signal transduction_Adenosine A1 receptor signaling pathway
Muscle contraction_Oxytocin signaling in uterus and mammary gland
Development_Alpha-2 adrenergic receptor activation of ERK
dGTP metabolism
Signal transduction_mTORC2 upstream signaling
Role of Tissue factor-induced Thrombin signaling in cancerogenesis
Saturated fatty acids synthesis to hexadecanoic acid
Immune response_Reactive oxygen species (ROS) in IL-4 signaling
Pyruvate metabolism
TTP metabolism
Retinol metabolism
Regulation of lipid metabolism_Alpha-1 adrenergic receptors signaling via arachidonic acid
DNA damage_ATM activation by DNA damage
CTP/UTP metabolism
Sphingolipid metabolism
Regulation of lipid metabolism_Stimulation of Arachidonic acid production by ACM receptors
dCTP/dUTP metabolism
Peroxysomal straight-chain fatty acid beta-oxidation
Development_NCAM1-mediated neurite outgrowth, synapse assembly and neuronal survival
Transport_ACM3 signaling in lacrimal glands
Renal secretion of organic electrolytes / Rodent version
Immune response_IL-5 signaling via PI3K, MAPK and NF-kB
Aminoacyl-tRNA biosynthesis in mitochondrion
Neurophysiological process_NMDA-dependent postsynaptic long-term potentiation in CA1 hippocampal neurons
Androgen biosynthetic pathways
Peroxisomal branched chain fatty acid oxidation
ATP/ITP metabolism
Cholesterol metabolism
dATP/dITP metabolism
Bile Acid Biosynthesis